The antihyperalgesic and antiallodynic effects of oxycodone plus ultra-low-dose NTX (Oxytrex, Pain Therapeutics, Inc., San Mateo, CA) suggest a promising new treatment for neuropathic pain.
Very interesting article. Early Progesterone treatment, in animal model, shown to improve neuropathic pain recovery. This is by no means the first study to show this. This has been shown numerous times in TBI, but the timing of therapy was the purpose of this article. What is very interesting here is that the metabolites implicated here in the recovery are the same metabolites implicated in an increased tumor potential.
Great article. Really shows the depth of the androgens and androgen metabolites in diabetes and diabetic complications. In this study, DHT and its metabolis 3-alpha androstanediol were shown to reduce inflammation and pain associated with diabetic neuropathy. Significant reduction in inflammation signaling (IL-1beta, TNF-alpha) was seen as was potential neurodegenerative processes (glutamate release and astrocyte immunoreactivity).